Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Constituent 1
Reference substance name:
Valproic acid
IUPAC Name:
Valproic acid
Details on test material:
- Supplied by Parke-Davis Pharmaceutical Research Division
- The percentages of active component (valproic acid) were determined by a gas-chromatographic assay for purposes of dose calculation.

Study design

Analytical method:
gas chromatography

Results and discussion

Partition coefficient
Key result
Type:
log Pow
Partition coefficient:
1.59
Temp.:
22.1 °C
pH:
5

Applicant's summary and conclusion

Conclusions:
Valproic acid has a log Pow of 1.59.