Registration Dossier
Registration Dossier
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EC number: 202-777-3 | CAS number: 99-66-1
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- dynamic method
Test material
- Reference substance name:
- Valproic acid
- IUPAC Name:
- Valproic acid
- Details on test material:
- - Supplied by Parke-Davis Pharmaceutical Research Division
- The percentages of active component (valproic acid) were determined by a gas-chromatographic assay for purposes of dose calculation.
Constituent 1
Results and discussion
Vapour pressureopen allclose all
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0.8 Pa
- Key result
- Temp.:
- 25 °C
- Vapour pressure:
- 1.3 Pa
Vapour pressure at 50°C (if relevant for classification of gas under pressure)
- Key result
- Vapour pressure:
- 13.7 Pa
Any other information on results incl. tables
The vapour pressure of the test item was calculated by extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50°C, according to Regulation EC No. 440/2008 Method A.4. and OECD Guideline 104.
Applicant's summary and conclusion
- Conclusions:
- Valproic acid has a vapour pressure of 0.8, 1.3 and 13.7 Pa at 20, 25 and 50°C, respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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