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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
Rheinland-Pfalz, Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht

Test material

Constituent 1
Chemical structure
Reference substance name:
Silicic acid, aluminum magnesium sodium salt
EC Number:
234-919-5
EC Name:
Silicic acid, aluminum magnesium sodium salt
Cas Number:
12040-43-6
Molecular formula:
Na(0.017-1.739)Mg(0.008-0.823)Al(0.002-0.2473)SiO(2.018-3.837)
IUPAC Name:
aluminium(3+) magnesium(2+) sodium tris(oxosilanebis(olate))
Test material form:
solid: particulate/powder
Specific details on test material used for the study:
Name Silicic acid Aluminium Magnesium Sodium Salt
Batch no. code # 1107274003
Appearance white powder
Composition Silic acid Aluminium Magnesium Sodium Salt
CAS No. 12040-43-5
EINECS-No. 234-919-5
Purity > 99 %
Homogeneity homogeneous
Stability stable at room temperature
Solubility poorly soluble
Expiry date 01. Nov. 2018
Storage room temperature (20 ± 5 °C), dry

In vitro test system

Test system:
artificial membrane barrier model
Source species:
other: synthetic macromolecular bio-barrier
Control samples:
yes, concurrent negative control

Test animals

Species:
other: synthetic biobarrier
Details on test animals or test system and environmental conditions:
The Corrositex® test is an in vitro procedure by which the assessment of corrosivity is not carried out in live animals.
The Corrositex® test refers to the penetration of the membrane barrier which is measured by a change in the colour of a pH indicator dye.

Test system

Controls:
yes, concurrent positive control
Duration of treatment / exposure:
60 min

Results and discussion

In vitro

Resultsopen allclose all
Irritation / corrosion parameter:
penetration time (in minutes)
Run / experiment:
negative control
Value:
> 60
Negative controls validity:
valid
Irritation / corrosion parameter:
penetration time (in minutes)
Run / experiment:
positive control
Value:
ca. 12
Positive controls validity:
valid
Irritation / corrosion parameter:
penetration time (in minutes)
Run / experiment:
test item
Value:
> 60
Remarks on result:
no indication of irritation

Any other information on results incl. tables

The controls showed the following results: The negative control showed no break-through within the observation time of 60 min.

The positive control showed clear corrosive effects after 12 minutes and is consequently classified as a corrosive substance belonging to UN Packing Group II.

Therefore the test item (substance category 2 according to the categorisation) is classified as a non-corrosive substance.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Silicic acid Aluminium Magnesium Sodium Salt is considered as not corrosive in the Corrositex® - Test.