Registration Dossier
Registration Dossier
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EC number: 206-735-5 | CAS number: 371-40-4
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 371-40-4
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:DK-EPA
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- Multicase model is used to estimate LC50 (48h) of Daphnia.
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-fluoroaniline
- EC Number:
- 206-735-5
- EC Name:
- 4-fluoroaniline
- Cas Number:
- 371-40-4
- Molecular formula:
- C6H6FN
- IUPAC Name:
- 4-fluoroaniline
- Details on test material:
- - Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- other: Estimation
- Water media type:
- not specified
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 3.2 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
Applicant's summary and conclusion
- Conclusions:
- The LC50 value of 4-fluoroaniline to Daphnia magna during a 48hr exposure is 3.2 mg/L
- Executive summary:
The EC50 value of 4-fluoroaniline to Green algae during a 48 hr exposure is estimated to be 3.2 mg/L.Though short term toxicity values to aquatic species indicate that the chemical could be classified for aquatic toxicity, but since 4-fluoroaniline is readily biodegradable in water and also is very water soluble and given the large dilution possibility in the aquatic environment, it is concluded that 4-fluoroaniline shall not exhibit toxicity to the aquatic organisms and the aquatic environment.
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