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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

pH

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Administrative data

Endpoint:
pH
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Cross-reference
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
pH
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Reason / purpose for cross-reference:
reference to same study
Qualifier:
no guideline followed
Principles of method if other than guideline:
AMP (two grades) was prepared at specific concentrations in DI Water and undiluted. The pH was determined at room temperature following calibration of the instrument with pH 4, 7, and 10 buffers.
GLP compliance:
no
Specific details on test material used for the study:
AMP-95: industrial grade
pH value:
13.4
Concentration:
other: as is
pH value:
12
Concentration:
10 other: %w/w
pH value:
11.2
Concentration:
1 other: %w/w
pH value:
10.7
Concentration:
0.1 other: %w/w
pH value:
10.3
Concentration:
0.01 other: %w/w
pH value:
9.6
Concentration:
0.001 other: %w/w
pH value:
8.2
Concentration:
0 other: %w/w

Using regression over the 7 experimental points, the pH curve could be modelled as follows:


pH = 0.3309 ln(Concentration in % w/w) + 11.548, with R² = 0.9658

Executive summary:

pH of AMP-95 (industrial grade) was measured at room temperature on a series of 10-fold dilutions in DI water, ranging 0.0001% to neat (as is). The pH curve could be modelled as follows:
pH = 0.3309 ln(Concentration in % w/w) + 11.548, with R² = 0.9658
This equation will be used in toxicology studies carried out on industrial grades of AMP to estimate what the pH of treated diet or dosage forms would have been if AMP hadn't been tested neutralized (as AMP-HCl notably).

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2023
Report date:
2023

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
AMP (two grades) was prepared at specific concentrations in DI Water and undiluted. The pH was determined at room temperature following calibration of the instrument with pH 4, 7, and 10 buffers.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-amino-2-methylpropanol
EC Number:
204-709-8
EC Name:
2-amino-2-methylpropanol
Cas Number:
124-68-5
Molecular formula:
C4H11NO
IUPAC Name:
2-amino-2-methylpropan-1-ol
Details on test material:
The test material used was AMP, however the purity of it is not specifically stated, although the author does indicate that all test materials were of a high degree of purity. No scoring of erythema/odema given.
Specific details on test material used for the study:
AMP ULTRA PC 2000 (high-purity grade)

Results and discussion

pH valueopen allclose all
pH value:
13.1
Concentration:
other: as is
pH value:
11.8
Concentration:
10 other: %w/w
pH value:
11.4
Concentration:
1 other: %w/w
pH value:
10.6
Concentration:
0.1 other: %w/w
pH value:
10.1
Concentration:
0.01 other: %w/w
pH value:
9.4
Concentration:
0.001 other: %w/w
pH value:
8.3
Concentration:
0 other: %w/w

Any other information on results incl. tables

Using regression over the 7 experimental points, the pH curve could be modelled as follows:


pH = 0.3189 ln(Concentration in % w/w) + 11.401, with R² = 0.9826

Applicant's summary and conclusion

Executive summary:

pH of AMP Ultra PC 2000 (high-purity grade) was measured at room temperature on a series of 10-fold dilutions in DI water, ranging 0.0001% to neat (as is). The pH curve could be modelled as follows:
pH = 0.3189 ln(Concentration in % w/w) + 11.401, with R² = 0.9826
This equation will be used in toxicology studies carried out on high-purity grades of AMP to estimate what the pH of treated diet or dosage forms would have been if AMP hadn't been tested neutralized (as AMP-HCl notably).