Registration Dossier
Registration Dossier
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EC number: 203-689-8 | CAS number: 109-63-7
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standards
- GLP compliance:
- no
Test material
- Reference substance name:
- Diethyl ether-boron trifluoride
- EC Number:
- 203-689-8
- EC Name:
- Diethyl ether-boron trifluoride
- Cas Number:
- 109-63-7
- Molecular formula:
- BF3C4H10O
- IUPAC Name:
- (diethyloxo)trifluoro-λ⁵-borane
- Details on test material:
- Name of the test substance used in the study report: Borfluorid-Ethyletherat
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- Mean body weight of the animals: 2.9 kg
The animals were offered a standard laboratory animal diet and drinking water ad libitum.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Amount / concentration applied:
- about 50 ul
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- The test substance was instilled into the conjunctival sac of one eye of the rabbit.
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye)
- Remarks:
- Migrated information
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