Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-689-8 | CAS number: 109-63-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
No data are available for acute oral toxicity.
The acute inhalation toxicity of boron trifluoride dihydrate (CAS: 13319 -75 -0) was tested using male and female Fischer-344 -rats. Aerosol concentrations were 1.01, 1.22, 1.32 or 1.54 mg/l for 4 hours. Clinical signs elicited by the exposures included dry and moist rales, gasping excessive, oral and nasal discharge, lacrimation, indicative of respiratory distress and irritation. Recovery was apparent for the rats surviving beyond 6 days post-exposure. Mortalities: 9/10 at 1.54 mg/l; 8/10 at 1.32 mg/l; 2/10 at 1.22 mg/l; 3/10 at 1.01 mgl/l. The LC50 was found to be 1.21 mg/l/4 hours for male and female rats (Rusch et al., 1986).
In an inhalation hazard test (BASF, 1982) using a concentration of 15 mg/l (= 2530 ppm) one male rat died after 3 -min exposure. During the 10- and 30-min exposures, one male rat of each group died, while during the 60-min exposure 1 male and 1 female animal died. Clinical signs reported were rough fur, corneal opacity, dyspnoea, laboured breathing and cyanosis. Some of the rats had erosions. In a part of the surviving animals, these signs were still to be seen at the end of the 14-day recovery period. Gross pathology: The heart was dilated and showed congestive hyperemia. The lungs were distended and partially filled with blood. In the trachea and bronchi, a high degree of foam formation was found.
No data are available for acute dermal toxicity.
Justification for classification or non-classification
Due to the corrosivity of diethyl ether boron trifluoride, testing regarding acute oral, dermal and inhalation toxicity is not meaningful.
The structure-related test compound boron trifluoride is classified with T+ and R26 (EC) and Acute Tox. Cat. 2, H 330 (GHS). For test compound boron trifluoride dihydrate proposal for classification is Acute Tox. Cat. 4, H332 (GHS) and Xn, R20 (EC).
Classification proposal based on the available data of BF3 dihydrate: according to EU = Xn; R20/22 - according to GHS: Acute Tox. 4 (H302 and H332).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
