Diethyl ether-boron trifluoride

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well described study based on BASF internal standards

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Principles of method if other than guideline:

according to BASF-internal standards

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Diethyl ether-boron trifluoride

EC Number:

203-689-8

EC Name:

Diethyl ether-boron trifluoride

Cas Number:

109-63-7

Molecular formula:

BF3C4H10O

IUPAC Name:

(diethyloxo)trifluoro-λ⁵-borane

Details on test material:

Name of the test substance used in the study report: Borfluorid-Ethyletherat

Test animals

Species:

rabbit

Strain:

Vienna White

Details on test animals or test system and environmental conditions:

Mean animal body weight: 2.9 kg. The animals were offered a laboratory animal standard diet (Ssniff) and water ad libitum.

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

other: untreated skin of the same animal

Amount / concentration applied:

Patch test, soaked with the undiluted test substance

Duration of treatment / exposure:

1 min, 5 min, 15 min, 20 hours

Observation period:

8 days

Number of animals:

4

Details on study design:

After the 5- or 15-min application, only the treated skin areas were rinsed with undiluted Lutrol 9 and thereafter with a 50% aqueous Lutrol solution.

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 15 min

Score:

4

Max. score:

4

Reversibility:

not reversible

Irritant / corrosive response data:

24 hours after the 1-min application, the skin was partly reddened in patches, after the 5-min. application slight necroses occurred in parts. In addition, 24 hours after the applications lasting 15 minutes and 20 hours, the skin was necrotic throughout and corroded down to the muscle. Due to the strong corrosive effects, two animals had to be sacrificed 24 hours and three days after application, respectively.

Any other information on results incl. tables

Table of effects

Time of incubation	Effects after 24 h	additional information
1 min	R+
5 min	N+
15 min	N+++ (muscle visible)	Killing of the animals for human reasons
20 h	N+++ (necrosis includes muscle)	Killing of the animals for human reasons
20 h (ear)	N+++; E+++

N = necrosis

R = reddening

E = edema

(+) = no clear effects

+ = slight

++ = strong

+++ = very strong

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information