Registration Dossier
Registration Dossier
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EC number: 223-453-8 | CAS number: 3900-45-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, basic and micronucleus tests.
- Author:
- Wild, D.
- Year:
- 1 983
- Bibliographic source:
- Food and Chemical
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- WHO
- Year:
- 2 001
- Bibliographic source:
- WHO Food Additive Series: 48
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- standard Ames assay
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2'-acetonaphthone
- EC Number:
- 202-216-2
- EC Name:
- 2'-acetonaphthone
- Cas Number:
- 93-08-3
- Molecular formula:
- C12H10O
- IUPAC Name:
- 1-(2-naphthyl)ethanone
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material: 2'-acetonaphthone
- Substance type: Organic
- Physical state: Solid
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Additional strain / cell type characteristics:
- not specified
- Species / strain / cell type:
- S. typhimurium TA 1538
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- no data
- Test concentrations with justification for top dose:
- 3600 µg/plate
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Species / strain:
- S. typhimurium TA 1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
No reverse mutation was reported in the standard Ames assay with various strains of Salmonella typhimurium (TA98, TA100, TA1535, TA1537, TA1538) incubated with 3600 µg/plate of 2'- acetonaphthone with and without metabolic activation. - Executive summary:
No reverse mutation was reported in the standard Ames assay with various strains of Salmonella typhimurium (TA98, TA100, TA1535, TA1537, TA1538) incubated with 3600 µg/plate of 2'- acetonaphthone with and without metabolic activation.
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