1-(6-methoxy-2-naphthyl)ethan-1-one

Endpoint summary

Additional information

Short term toxicity to Fish :

Based on the various studies available with Klimish rating 2 and 4 for the target substance CAS NO 39004506 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	LC50	15.18299 mg/l	mortality	96 hrs	Lepomis macrochirus	Predicted data for target chemical
2	LC50	42.9921 mg/l	mortality	96 hrs	Oncorhynchus mykiss	Predicted data for target chemical
3	LC50	5.21 mg/l	mortality	96 hrs	Pimephales promelas	Data from DEPAof CAS NO 93-08-3
4	LC50	15.2 mg/l	mortality	48 hrs	Pimephales promelas	Data from study report for CAS NO 119-61-9
5	EC50	14.9 mg/l	mortality	24 hrs	Pimephales promelas	Data from study report for CAS NO 119-61-9

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC50 values was found to be in range of 5.21 to42.9921mg/l in 96 hrs and 48 hrs and the EC50 value was found to be 14.9 mg/l in 24 hrs on the basis of mortality effect . But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable.Thus considering the CLP Criteria for aquatic classification of the substance,, it is concluded that 1-(6-methoxy-2-naphthyl) ethan-1-one does not exhibit short term toxicity to fish (Lepomis macrochirus,Oncorhynchus mykiss and Pimephales promelas)

Longterm toxicity to fish:

According to column I of Annex IX, Long-term toxicity testing on fish need not to be conducted as it is already provided as part of Annex VIII requirements.Therefore this study was considered to be waived.

Toxicity to aquatic Invertebrate :

Based on the various studies available with Klimish rating 2 and 4 for target chemical CAS NO 3900-45-6 and the read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	LC50	23.43862 mg/l	mortality	24 hrs	Daphnia magna	Predicted data for target chemical
2	EC50	44.11281 mg/L.	mortality	48 hrs	Daphnia magna	Predicted data for target chemical
3	LC50	15.76 mg/L.	mortality	48 hrs	Daphnia longispina	Data is from DEPA
4	LC50	82 mg/L.	mortality	48 hrs	Daphnia longispina	Data from publication for CAS no 22204-53-1

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that LC50 value is expected to be in range of 15.76 to 82 mg/l and EC50 value was found to be44.11281 mg/l in a 48 hrs study on the basis of mortality effect. But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable.

Thus considering the CLP Criteria for aquatic classification of the substance it is concluded that the substance 1-(6-methoxy-2-naphthyl) ethan-1-one is not toxic to aquatic invertebrate (Daphnia magna, Daphnia longispina)

Long term toxicity to aquatic invertebrate:

According to column I of Annex IX, Long-term toxicity testing on aquatic invertebrate need not to be conducted as it is already provided as part of Annex VIII requirements.Therefore this study was considered to be waived.

Toxicity to aquatic Algal :

Based on the various studies available with Klimish rating 2 and 4 for the target substance CAS NO 3900-45-6 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	EC50	24.74008 mg/l	growth	72 hrs	Pseudokirchneriella subcapitata	Predicted data for target chemical
2	EC50	12.25381 mg/l	population	72 hrs	Pseudokirchneriella subcapitata	Predicted data for target chemical
3	EC50	34.86615mg/l	-	-	Seleriastrum Capricornutum	Data is from DEPA
4	EC50	42mg/l	mortality	24 hrs	Chlorella vulgaris	Data from publication for CAS no 22204-53-1
5	EC50	40 mg/l	mortality	24 hrs	Ankistrodesmus falcatus	Data from publication for CAS no 22204-53-1

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that EC50 value is expected to be in range of12.25381 to42 mg/l in 24 hrs to 72 hrs study on the basis of growth, population and mortality effect. But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable.

Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that1-(6-methoxy-2-naphthyl) ethan-1-one does not exhibit toxicity to green algae (Pseudokirchnerella subcapitata, Chlorella vulgaris, Ankistrodesmus falcatus  and Seleriastrum Capricornutum.)

Toxicity to microorganism:

Based on the various studies available with Klimish rating 2 for the target substance CAS NO 3900-45-6 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	IC50	108.7335 mg/l	Population	48 hrs	Tetrahymena pyriformis	Predicted data for target chemical
2	IGC50	25.04128 mg/l	growth	48 hrs	Tetrahymena pyriformis	Predicted data for target chemical
3	IGC50	18.3244 mg/l	-	46 hrs	Tetrahymena pyriformis	Predicted data for target chemical
4	IGC50	17 mg/l	growth inhibition	48 hrs	Tetrahymena pyriformis	Data from publication for CAS no 93-04-9

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that IGC50 value is expected to be in the range of 17-108.7335 mg/l in 46 to48 hrs study.