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EC number: 608-929-9
CAS number: 33955-44-1
The potential of the test substance to cause damage to the conjunctiva,
iris or cornea was assessed in 3 White New Zealand rabbits, subjected to
a single ocular application of 0.1 ml bulk volume (about 24 mg) of the
test substance. About 24 hours after application the eye was rinsed with
tap water. The ocular reactions were assessed approximately 1, 24, 48,
72 hours and 7 days after application. Slight to moderate swelling and
discharge were observed in all animals on the day of application. Index
for conjunctival redness could not be read in all animals on this day
because of staining due to the color of the test substance. 24 hours
after application additionally moderate conjunctival redness was noted
in all animals and slight corneal opacity was seen in 1 animal. The
ocular reactions were reversible in all animals within 7 days after
application at latest. The average scores (24 to 72 hours) for
irritation were calculated to be 0.2 for corneal opacity, 0.0 for iris,
1.9 for conjunctival redness and 0.7 for chemosis. Based on the average
conjunctival redness scores of 2 in two out of three animals, the
substance is considered to be irritating to the eye of the rabbit.
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