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EC number: 608-929-9
CAS number: 33955-44-1
An acute oral toxicity following OECD guideline 4223 and in compliance
with GLP was performed to assess the test article's acute oral toxicity
in Wistar rats. A single dose of 2000 mg/kg body weight of the test
material preparation in 0.5 % Tylose CB 30.000 in Aqua bidest. was given
to six fasted animals (three males and three females) by gavage in
sequential manner. No mortality occurred. No signs of toxicity were
observed in the male animals. Signs of toxicity noted in the 2,000 mg/kg
dose group in the female animals comprised impaired and poor general
state, dyspnoea, apathy, staggering, ataxia and piloerection. Findings
were observed from 2 hours after application until including study day
3. The animals gained weight throughout the study period. No
abnormalities were noted at necropsy of the animals at the end of the
study. Under the conditions of this study the median lethal dose of the
test substance after oral application was found to be greater than 2000
mg/kg body weight for the male and female animals.
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