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EC number: 608-929-9
CAS number: 33955-44-1
The potential of the test substance to cause acute dermal irritation or
corrosion was assessed by a single topical application of 0.5 g of the
test substance to the intact skin of 3 White New Zealand rabbits for 4
hours under semiocclusive dressing. After removal of the patch the
application area was washed off. The cutaneous reactions were assessed
approximately 1, 24, 48 and 72 hours after removal of the patch and then
in weekly intervals until day 14. Index for erythema could not be read
in all animals because of staining due to the color of the test
substance. No edema was observed in all animals over the observation
period. In two animals evaluation of erythema was applicable 72 hours
respectively 14 days after removal of the patch. No erythema was noted.
The average score (24 to 72 hours) for irritation was calculated to be
0.0 for edema. Considering the non-observed cutaneous reactions as well
as the average score for irritation, the test substance does not give
indication of an irritant property to the skin under the test conditions
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