Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Eye irritation
Some information in this page has been claimed confidential.
Administrative data
- Endpoint:
- eye irritation, other
- Type of information:
- other: QSAR and Read-Across; supoorting evidence
- Adequacy of study:
- supporting study
- Study period:
- December 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Results derived from valid (Q)SAR models, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification. Additional information from read-across.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
- Principles of method if other than guideline:
- OECD QSAR toolbox, EPI (Estimation Programs Interface) Suite™ and Read Across were applied.
- GLP compliance:
- not specified
Test material
- Test material form:
- liquid: viscous
- Details on test material:
- batch number: 616F-2072 (NBK-003072-796)
Constituent 1
Results and discussion
Any other information on results incl. tables
- EPI suite: the structures of the selected peaks of the test substance are not included in QSAR domain: final SAR results are “undefined”
- Read Across cannot be applied, since no structures similar to the selected peaks of the testsusbtance – and with known toxicological information - were found in public sources. Looking at substructures of the peaks, no robust conclusion on eye irritating potential can be drawn.
Applicant's summary and conclusion
- Interpretation of results:
- other: Inconclusive
- Executive summary:
Due to the physical characteristics of the test item, testing on eye irritation according to OECD Guideline 437 was not possible
To gather some indication on the eye irritation potential of the test substance,OECD QSAR toolbox, EPI (Estimation Programs Interface) Suite™ and Read Acrosswere applied.
No conclusions could be drawn on eye irritation potential of the testsubstance from the predictive tools.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
