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Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Referenceopen allclose all

Endpoint:
acute toxicity: oral
Type of information:
other: bibliography
Adequacy of study:
weight of evidence
Study period:
1976
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
according to guideline
Guideline:
other: Moreno protocol on essential oils
GLP compliance:
not specified
Species:
rat
Dose descriptor:
LD50
Effect level:
3 650 mg/kg bw
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 Rat oral of g-terpinene is 3650mg/kg.The substance is classified as a category 5 GHS regulation.
Endpoint:
acute toxicity: oral
Type of information:
other: bibliography
Adequacy of study:
weight of evidence
Study period:
2008
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data considered reliable by ECHA.
Qualifier:
no guideline available
Principles of method if other than guideline:
Unknown
GLP compliance:
not specified
Details on oral exposure:
LD50 Rat oral 2790 mg/kg (2440-3180, 95% CL) /From table/[Organization for Economic Cooperation and Development; Screening Information Data Set for LINALOOL (78-70-6) p.13 (March 2002). Available from, as of July 15, 2008: http://www.chem.unep.ch/irptc/sids/OECDSIDS/sidspub.html] **PEER REVIEWED**
Dose descriptor:
LD50
Effect level:
2 790 mg/kg bw
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 Rat oral 2790 mg/kg. The substance is classified as a category 5 GHS regulation.
Endpoint:
acute toxicity: oral
Type of information:
other: bibliography
Adequacy of study:
weight of evidence
Study period:
2006
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data considered reliable by ECHA.
Qualifier:
no guideline available
Principles of method if other than guideline:
Unknown
GLP compliance:
not specified
Details on test animals or test system and environmental conditions:
LD50 Rat oral 4750 mg/kg [O'Neil, M.J. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ:Merck and Co., Inc., 2006., p. 464] **PEER REVIEWED**
Dose descriptor:
LD50
Effect level:
ca. 4 750 mg/kg bw
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The LD50 rat oral 4750 mg/kg body weight. The substance is classified as a category 5 GHS regulation.
Endpoint:
acute toxicity: oral
Type of information:
other: bibliography
Adequacy of study:
weight of evidence
Study period:
2000
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data considered reliable by ECHA.
Qualifier:
no guideline available
Principles of method if other than guideline:
Unknown
GLP compliance:
not specified
Details on oral exposure:
LD50 Rat oral 980 mg/kg [Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 3463] **PEER REVIEWED**
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 980 mg/kg bw
Based on:
not specified
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
LD50 rat oral 980 mg/kg body weight

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1979
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Monograph used by the fragrance industry.
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
RIFM protocol in 1973
GLP compliance:
no
Species:
rat
Key result
Sex:
not specified
Dose descriptor:
approximate LD50
Effect level:
> 3 750 - < 5 670 mg/kg bw
Based on:
not specified
Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
The acute oral LD50 value in rats was reported 4.70 g/kg (Moreno, 1973).
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
discriminating dose
Value:
980 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification