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EC number: 285-397-0
CAS number: 85085-75-2
Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Thymus zygis, Labiatae.
Thyme essential oil had no mutagenic or DNA-damaging activity in either
the Ames test (strains TA1535, TA1537, TA98, TA100, with and without
metabolic activation, 0.25 and 0.5 µl essential oil/plate) or Bacillus
subtilis rec-Assay (10 µl and 30 µl essential oil)(Zani et al., 1991).
Although the Ames test lacked one of the currently used strains the
negative result could be regarded reliable, because the paper contains
adequate description of findings and because the Ames test is
supplemented by the rec-assay. This was confirmed by Shoeibi et al.,
2009: Thyme essential oil in concentrations of 50–2000 µg/ml did not
show signs of mutagenicity in an Ames test using Salmonella typhymurium
strain TA100 with and without rat liver S9.
Mutagenicity test results of Thyme
* Mean: Average of colonies in triplicate plates
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