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EC number: 206-596-0 | CAS number: 355-93-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 March 2010 and 16 April 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 440/2008
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Sponsor's identification: Octafluoropentyl methacrylate
Purity >99% - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: control and each test group
- Sampling method: Samples were collected at 0 and 48 hours, replicate test condition samples were pooled - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Diluting (with reconstituted water) a saturated solution prepared from an initial test item dispersion at a concentration of 100 mg/L. The test item was dispersed in reconstituted water with the aid of propeller stirring at approximately 1500 rpm for 24 hours. After 24 hours, the stirring was stopped and any undissolved test item was removed by filtration through a 0.2 µm Sartorius Sartopore filter.
- Controls: reconstituted water
- Evidence of undissolved material: none - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Source: in-house laboratory cultures
- Age of parental stock: first instar
- Feeding during test: None
ACCLIMATION
- Acclimation period: 24 hours, gravid adults were isolated
- Acclimation conditions: same as test; ensuring parthenogenesis
- Type and amount of food: fed daily with a suspension of algae - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg CaCO3 / L
- Test temperature:
- 20 - 21 °C
- pH:
- 7.7 - 8.0
- Dissolved oxygen:
- 8.4 to 9.3 mg O2/L
- Nominal and measured concentrations:
- Nominal Concentration: 1.7, 3.1, 5.4, 9.5, 17 mg/L
Geometric Mean Measured Concentration: 0.96, 1.9, 3.3, 5.8, 11 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 300 mL glass stoppered conical flasks
- Type: closed
- Material, size, headspace, fill volume: containing approximately 300 mL of test preparation; test vessels were completely filled and sealed to minimise losses through volatility
- Aeration: None
- No. of organisms per vessel: 10 organisms/vessel
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: reconstituted water
- Culture medium different from test medium: No
- Intervals of water quality measurement: 0 and 48 hours for pH and dissolved oxygen
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 16 hours light and 8 hours darkness, with 20-minute dawn and dusk transition periods
EFFECT PARAMETERS MEASURED: immobilisation or adverse reactions recorded 24 and 48 hours after start of exposure
RANGE-FINDING STUDY
- Test concentrations:
Initial range-finding test: 0.017, 0.17, 1.7 and 17 mg/L
Second range-finding test: 0.017, 0.17, 1.7 and 17 mg/L
- Results used to determine the conditions for the definitive study: Based on the results of the range-finding tests and initial experiment the following nominal test concentrations were assigned to the definitive test: 1.7, 3.1, 5.4, 9.5 and 17 mg/I (0.96, 1.9, 3.3, 5.8 and 11 mg/I based on geometric mean measured test concentrations). - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 11 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 100% v/v saturated solution
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 11 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 100% v/v saturated solution
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 11 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 100% v/v saturated solution
- Details on results:
- - Behavioural abnormalities: None reported
- Other biological observations: None reported
- Mortality of control: 0%
- Other adverse effects control: None
- Abnormal responses: None reported
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: Test preparation were observed to be clear, colourless solutions throughout the duration of the test. - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- Relevant effect levels: 48h EC50 0.65 mg/L - Validity criteria fulfilled:
- yes
- Conclusions:
- The acute toxicity of the test item to the freshwater invertebrate Daphnia magna has been investigated and gave a 48-Hour EC50, based on geometric mean measured test concentrations of greater than 11 mg/L. Correspondingly the No Observed Effect Concentration was 11 mg/L. This study showed that there were no toxic effects at saturation.
- Executive summary:
A GLP-complaint study according to OECD Guideline 202 was conducted to assess the acute toxicity of octafluoropentyl methacrylate to Daphnia magna. Following range-finding tests, twenty daphnids (2 replicates of 10 animals) were exposed to dilutions of a 100% v/v saturated solution of test item with geometric mean measured concentration of 0.96, 1.9, 3.3, 5.8 and 11 mg/L for 48 hours at approximately 20 °C under static conditions.
No toxic effects at saturation were reported. The 48-hour EC50 based on the geometric mean measured test concentrations was greater than 11 mg/L and correspondingly the No Observed Effect Concentration was 11 mg/L.
Reference
Description of key information
A GLP-complaint study according to OECD Guideline 202 was conducted to assess the acute toxicity of octafluoropentyl methacrylate to Daphnia magna. Following range-finding tests, twenty daphnids (2 replicates of 10 animals) were exposed to dilutions of a 100% v/v saturated solution of test item with geometric mean measured concentration of 0.96, 1.9, 3.3, 5.8 and 11 mg/L for 48 hours at approximately 20 °C under static conditions.
No toxic effects at saturation were reported. The 48-hour EC50 based on the geometric mean measured test concentrations was greater than 11 mg/L and correspondingly the No Observed Effect Concentration was 11 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 11 mg/L
Additional information
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