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EC number: 639-263-7
CAS number: 200575-15-1
In this in vitro assessment of the mutagenic potential of UK-220,955,
histidine dependent auxotrophic mutants of Salmonella typhimurium
(strains TA1535, TA1537, TA98 and TA100) were exposed to the test
substance, diluted in dimethyl sulphoxide which was also used as a
negative control. Two independent mutation tests were performed, in the
presence and absence of liver preparations from Aroclor 1254-induced
rats. In the preliminary toxicity test with dose levels of up to 5000
yg/plate no toxicity was observed. A top dose level of 5000 yg/plate was
chosen for the subsequent mutation study. Other dose levels used in the
mutation assays were: 1500, 500, 150 and 50 Ag/plate. No evidence of
mutagenic activity was seen at any dose level of UK-220,955 in either
mutation test. The concurrent positive control compounds demonstrated
the sensitivity of the assay and the metabolising activity of the liver
preparations. It is concluded that, when tested in dimethyl sulphoxide,
UK-220,955 shows no evidence of mutagenic activity in this bacterial
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