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EC number: 639-263-7
CAS number: 200575-15-1
A study was performed to assess the acute oral toxicity of UK-220,955 to
the rat. The method followed was that described in EEC Methods for the
determination of toxicity, Annex to Directive 92/69/EEC (OJ No. L383A,
29. 12.92), Part B, Method B.1 bis. Acute toxicity (oral) -Fixed Dose
A group of ten fasted rats (five males and five females) received a
single oral gavage dose of the test substance, formulated in 1 % w/v
aqueous methylcellulose and administered at a dose level of 2000 mg/kg
bodywcight. The dose level was chosen on the basis of preliminary study
investigations. All animals were killed and examined macroscopically on
Day 15, the end of the observation period.
Clinical signs of reaction to treatment included piloerection and
abnormal faeces, seen in all rats. There were no other signs of reaction
to treatment and recovery was complete in all animals by Day 2.
All rats were considered to have achieved satisfactory bodyvveight gains
during the study.
Macroscopic examination of animals killed on Day 15 revealed no
The discriminating dose to rats of UK-220,955 was demonstrated to be
2000 mg/kg bodyweight.
UK-220,955 will not require labelling in accordance with GHS
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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