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EC number: 430-150-6
CAS number: -
7.3.2/1: Eye irritation response data for each animal at each
Score at time point
1 h (Day 1)
0 / 0 / 0
1 / 0 / 0
2 / 2 / 2
1 / 1 / 1
3 / 3 / 2
24 h (Day 1)
2 / 1 / 1
1 / 0 / 1
48 h (Day 2)
72 h (Day 3)
2 / 0 / 2
0 / - / 0
2 / - / 2
1 / - / 1
Average 24, 48 and 72 h
0.3 / 0.0 / 0.0
0.0 / 0.0 / 0.0
2.0 / 0.7 / 1.3
1.0 / 0.0 / 1.0
1.0 / 0.0 / 0.3
Average time (unit) for reversion
72 h to 11 days
24 h to 7 days
24 h to 6 days
- : No reading
an eye irritation study performed according to the OECD Guideline No.
405, and in compliance with GLP, 0.1 mL of undiluted test material was
instilled into the right eye of 3 female New Zealand White rabbits. The
lids are then gently held together for about one second in order to
prevent loss of the material. The left eye remained untreated and served
as control. Animals were observed at 1, 24, 48 and 72 h after test
material instillation, and then on Days 5-11. The reactions in the
conjunctiva (redness, chemosis and discharge), the iris and the cornea
(opacity and area involved) were scored according to the Draize scale.
moderate irritation of the conjunctivae was observed in all animals and
a slight congestion of the iris was noted in one animal at 1 h after
instillation. 24 h after instillation, the discharges had nearly
disappeared and a conjunctival enanthema was noted in all animals with a
very slight oedema in two of them. Marked redness was observed and a
diffuse area of cornea opacity was reversible within 24 h in one animal.
No ocular reaction was observed in one animal at 72 h. A slight
palpebral irritation was noted in the two other animals. The chemosis
was reversible within 7 days and the palpebral redness disappeared 11
days after instillation.
individual scores at 24, 48 and 72 h after exposure for the 3 animals
were 0.3 / 0.0 / 0.0 for cornea score; 0.0 / 0.0 / 0.0 for iris score;
2.0 / 0.7 / 1.3 for conjunctivae score and 1.0 / 0.0 / 1.0 for chemosis
the test conditions, the test material is not classified as irritating
to eyes according to the criteria of the Annex VI of the Regulation (EC)
No. 1272/2008 (CLP) and according to the GHS.
study is considered as acceptable and satisfies the requirement for eye
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