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EC number: 430-150-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-02-02 to 2015-02-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- The study was conducted according to OECD/EC guideline, and under GLP. No deviation was reported. Test substance is adequately specified with purity. Therefore full validation applies.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- inspected on June 3 to 5, 2013 / signed on November 5, 2013
- Type of method:
- flask method
- Key result
- Water solubility:
- 195 mg/L
- Loading of aqueous phase:
- 0.85 g/L
- Temp.:
- 20 °C
- pH:
- 6.4
- Remarks on result:
- other: for double distilled water
- Water solubility:
- 193 mg/L
- Loading of aqueous phase:
- 0.85 g/L
- Temp.:
- 20 °C
- pH:
- 7.8
- Remarks on result:
- other: for daphnia M4 medium
- Details on results:
- Method Validation
Linearity: LOD = 0.15 mg/L
System quantification limit = 0.5 mg/L
range of nominal 0.5 - 100 mg/L (n = 9) with coefficient of determination for the linear calibration curve (r2) of 0.999932.
Limit of Quantification
Nominal LOQ = 2 mg/L
Accuracy and Precision
Double distilled water: Mean recovery rates were 92 % for the 1 x LOQ and 99 % for the 10 x LOQ (RSD ≤ 1.5 %)
Daphnia M4 medium: Mean recovery rates were 93 % for the 1 x LOQ and 98 % for the 10 x LOQ (RSD ≤ 2.5 %)
Specificity
Analyses were performed with DAD (diode array detection) as selective detector. Spectra of sample peaks were compared automatically by the software against spectra obtained from standard peaks. For all samples, a maximum spectra match angle of 6.301 was observed, the maximum observed match threshold was 16.555.
The spectral match angle was lower than the match threshold for all samples, confirming the identity of the analyte peaks. For the control samples, no significant signal could be detected, showing that blank values were lower than 30 % of the LOQ. - Conclusions:
- Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
- Executive summary:
The water solubility of the test substance was measured under GLP according OECD 105 guideline and EU A6 guideline, flask method.
The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with preincubation at 30 ± 0.5 °C. Three measurements were performed at 24, 48 and 72 h, with duplicate analysis. Equilibrium was considered achieved at first sampling interval (24 h) for both media (double distilled water and Daphnia M4 medium).
The analytical method (UPLC-DAD, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- From August 18 to 29, 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- The study was conducted according to OECD/EC/NF guideline, and under GLP. Test substance is adequately specified with purity. Validation applies, with restrictions due to lack of experimental details.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Qualifier:
- according to guideline
- Guideline:
- other: French standard NF T 20-046
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 0.27 g/L
- Temp.:
- 22 °C
- pH:
- 7
- Remarks on result:
- other: ± 1 °C
- Conclusions:
- Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
- Executive summary:
The water solubility of the test substance was measured under GLP according to OECD 105/EU A6 guidelines, flask method with HPLC-UV analysis. Three measurements were performed at 24, 48 and 72 h. Equilibrium was considered achieved, and the mean value is retained.
Referenceopen allclose all
Preliminary Test (non GLP): The determined solubility in double distilled water was in the range of 0.136 - 0.17 g/L. For the application dose for the definitive study, 0.85 g/L, as approx. the fivefold of the solubility result, was used.
Table 4.8/1: Water Solubility Results at 20 °C for test item in Double Distilled Water
Preincubation time |
Replicate No. |
Test item (mg/L) |
|
Concentration1 |
Mean |
||
24 h |
1 |
185 |
190
|
2 |
196 |
||
48 h |
1 |
195 |
194
|
2 |
193 |
||
72 h |
1 |
197 |
199
|
2 |
200 |
||
Mean (24 - 72 h) |
195 |
||
Deviation [%] (24 - 72 h) |
4.3 |
1Mean value of double injections, dilution factor of 4 taken into account
Table 4.8/2: Water Solubility Results at 20 °C for test item in Daphnia M4 Medium
Preincubation time |
Replicate No. |
Test item (mg/L) |
|
Concentration1 |
Mean |
||
24 h |
1 |
198 |
195
|
2 |
191 |
||
48 h |
1 |
192 |
194
|
2 |
197 |
||
72 h |
1 |
196 |
191
|
2 |
187 |
||
Mean (24 - 72 h) |
193 |
||
Deviation [%] (24 - 72 h) |
2.0 |
1Mean value of double injections, dilution factor of 4 taken into account
Equilibrium was considered achieved at first sampling interval (24 h) in both media.
The solubilities determined for the two test media did not differ significantly.
Validity Criteria
The validity criteria were fulfilled:
The concentration measured at each sampling time did not differ for more than 15 %.
Temperatures were kept constant within ± 0.5 °C.Table 4.8/1: Water solubility – results
|
24- hour |
48- hour |
72- hour |
T (°C) |
22 |
22 |
22 |
pH |
7 |
7 |
7 |
Mass concentration (g/L) |
0.28 |
0.26 |
0.26 |
Mean value: 0.27 g/L
The repeatability of these tests is 3.5 % (< 15 %).
Description of key information
Moderately soluble. Equilibrium after 24h.
pH of saturated solution: 6.4
Key value for chemical safety assessment
- Water solubility:
- 195 mg/L
- at the temperature of:
- 20 °C
Additional information
Two reliable studies, conducted according to recognized OECD/EC method and under GLP, are available, and provide quite consistent results. Both were performed with the flask method, but experimental details were lacking in the INERIS 1998 study, leading to minor restrictions on accuracy, while the more recent one (Noack 2015), performed with fully validated analytical method, is considered of higher quality. Therefore the Noack result is preferred and retained as key data, rather than the mean value.
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