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Boiling point

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boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From September 11 to 22, 1997
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
The study was conducted according to OECD/EC guideline, and under GLP. The substance is considered to be adequately characterised with its purity. Therefore full validation applies.
according to guideline
OECD Guideline 103 (Boiling point/boiling range)
according to guideline
EU Method A.2 (Boiling Temperature)
Principles of method if other than guideline:
Not applicable
GLP compliance:
(no certificate)
Type of method:
method according to Siwoloboff
Boiling pt.:
218.1 °C
Atm. press.:
100.28 kPa
Remarks on result:
other: measured
Key result
Boiling pt.:
219.4 °C
Atm. press.:
101.325 kPa
Remarks on result:
other: corrected

The test substance being a liquid at room temperature, a preliminary test was performed, increasing the temperature by steps of 50 °C until an approximate boiling point was observed, i.e. ca. 218 °C.

The temperature of the heating bath was set ca. 200 °C, and a heating rate of the bath of 1 °C/minute is applied.


Table 4.3/1: Boiling point – results


Test No.

Boiling point, as observed, non-corrected

1 (± error)

217.9 °C ± 0.1

2 (± error)

218.0 °C ± 0.1

3 (± error)

218.3 °C ± 0.1

Mean ± standard deviation

218.1 °C ± 0.2


The rough values are corrected by:

- the calibration correction of the thermometer,

- the emerging column correction,

- the barometric pressure correction, using a value of the factor calculated by interpolation of literature factors of reference substances which have their boiling point slightly higher, respectively lower, than the test substance, i.e. terbutyltoluene and diethyleneglycol mono n-butyl ether

The cumulative effect of standard deviation, measurement incertitude and correction incertitude lead to a boiling point of: 219.4 ± 0.4 °C (492.6 ± 0.4 K)
Executive summary:

The boiling point of the test substance was determined under GLP according to OECD 103/EU A2 guideline, Siwoloboff (capillary) method. Three main runs were performed, and the mean final temperature was retained.

The boiling temperature of the test substance has been determined to be 218.1°C under 100.28 kPa, and 219.4°C as corrected to normal atmospheric pressure.

Description of key information

Measured boiling point = 218.1°C under 100.28 kPa; Corrected boiling point = 219.4°C at normal atmP

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
219.4 °C

Additional information

A fully reliable experimental study, conducted according to a recognized OECD/EU method, is available. It is considered as a key study, and the result is retained as key data.