Registration Dossier
Registration Dossier
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EC number: 407-770-0 | CAS number: 61597-96-4 D(+)-LACTATE D'ISOBUTYLE
Dissociation constant
Administrative data
Link to relevant study record(s)
Description of key information
Isobutyl-R-lactate does not dissociate within the pH range prescribed by OECD test guideline 112.
Key value for chemical safety assessment
Additional information
The determination of the dissociation constant in water was not successful because the sample material does not dissociate within the range of validity of the OECD method. This result is in accordance to the literature (A. M. N. Silva, X. Kong and R. C. Hider, BioMetals 2009, 22(5), 771–778): The pKa value of the hydroxyl function in free lactic acid was found to be 15.1 and it can be assumed that the dissociation potential is further reduced in the esterificated compound (resulting in even higher pKa values).
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