Registration Dossier
Registration Dossier
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EC number: 606-826-3 | CAS number: 217308-07-1
Endpoint summary
Administrative data
Description of key information
LD50 (oral,rat): ca. 5000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are no studies available for (R)-ammonium mandelat, but for (R)- mandelic acid and mandelic acid sodium salt.
An acute toxicity study (similar to OECD 401) with (R)-mandelic acid was conducted by BASF AG (1987) groups of 10 rats were administered doses of 1470, 3160 and 5000 mg/kg bw by gavage and observed for 14 days for lethality and clinical signs of intoxication. The mortality rate was 0/10, 1/10 and 5/10 in the low, mid and high dose groups, respectively. Clinical symptoms at 3160 mg/kg bw was dyspnea, apathy, staggering, red-brown urine, piloerection and poor general state; these symptoms were observed until day 2 or 3. At 5000 mg/kg bw dyspnea, apathy, staggering, tremors, red-brown urine, piloerection and poor general state; these symptoms were observed until 5 hours after dosing (tremors) or even until day 1, 2 or 3. The LD50 was found to be approx. 5000 mg/kg bw. (BASF, 1987)
In an second study with mandelic acid sodium salt (43% in aqueous solution), groups of 10 rats were administerd doses of 2150 and 5000 mg/kg bw by gavage and observed for 14 days. There was no clinical symptoms or mortality observed. The LD 50 was found to be greater than 5000 mg/kg bw (BASF, 1979).
Justification for selection of acute toxicity – oral endpoint
most relevant study
Justification for classification or non-classification
No need for classification according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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