Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Water solubility

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From October 08, 2001 to October 19, 2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Water solubility:
223.85 g/L
Conc. based on:
test mat.
Incubation duration:
72 h
Temp.:
20 °C
pH:
7.3
Key result
Water solubility:
108 000 mg/L
Conc. based on:
act. ingr.
Temp.:
20 °C
pH:
7.3
Details on results:
The preliminary visual experiments showed that the water solubility of the test substance is between ca. 100 and 200 g/L. Therefore, the water solubility was determined by the flask-method.

Flask-Method


 


Table 2: Concentrations of experiment A to D






































Stirring time at 30°C (h)



mg/L



                Experiment A



24


 


 


 


mean



460.809


461.179


 


460.994



                Experiment B



48


 


 


mean



417.661


417.957


 


417.809



               Experiment C



72


 


 


mean



351.994


352.609


 


352.302



                      Experiment D (blank)



72


 


 


mean



-


-


 


-



 


Table 3: Concentrations of standards for recheck





















 



Standard F


(c=187.98 mg/L)



Standard D


(c=375.96 mg/L)



Found


mg/L


 


mean



188.631


188.524


 


188.577



377.023


375.795


 


376.409



%recovery



100.3



100.1



 


Table 4: Water solubility of the test substance






























































Experiment



A



B



C



D



Amount of test substance (g)



2.95960



3.51190



3.96489



0



pH at room temperature



7.3



7.3



7.2



6.7



aliquot (g)



0.10855



0.09265



0.14790



0.09885



volume (g)



49.64238



49.59866



49.76026



49.74886



aliquot (mL)



-



-



0.5



-



volume (mL)



-



-



1



-



Water solubility (g/L)



210.82



223.67



237.06



-



Average (experiments A to C): 223.85 g/L


Standard deviation: 13.12 g/L


Relative standard deviation: 5.86%

Conclusions:
Under the study conditions, the water solubility (corrected for purity) was found to be 108 g/L active ingredient at 20°C. Hence, the test substance is very soluble in water.
Executive summary:

A study was conducted to determine the water solubility of the test substance according to EU Method A.6 and OECD Guideline 105 in compliance with GLP.


 


The water solubility was determined by the flask method and the concentration by HPLC.


 


Under the study conditions, the water solubility (corrected for purity) was found to be 108,000 mg/L at 20°C based on active ingredient. Hence, the test substance is very soluble in water.

Description of key information

Under the study conditions, the water solubility (corrected for purity) was found to be 108,000 mg/L at 20°C. Hence, the test substance is very soluble in water.

Key value for chemical safety assessment

Water solubility:
108 000 mg/L
at the temperature of:
20 °C

Additional information