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EC number: 443-090-0 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From October 17, 2001 to November 19, 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- < -4.9
- Temp.:
- 25 °C
- Remarks on result:
- other: A significant dependency of the partition coefficient on the concentration could not be observed.
- Conclusions:
- Under the study conditions, the log Kow of the test substance was found to be <-4.9 at 25°C.
- Executive summary:
A study was conducted to determine the partition coefficient of the test substance according to EU Method A.8 and OECD Guideline 107 in compliance with GLP.
The n-octanol/water partition coefficient of the test substance at room temperature was performed according to the flask-shaking method. The log Kow of the test substance was determined using HPLC method.
Under the study conditions, the log Kow of the test substance was found to be <-4.9 at 25°C.
Reference
Table 2: Partition coefficients
Experiment
|
Pow |
log Pow |
Average log Pow |
1A |
<0.000012 |
<-4.9 |
<-4.9 |
1B |
<0.000012 |
<-4.9 |
|
2A |
<0.000012 |
<-4.9 |
<-4.9 |
2B |
<0.000012 |
<-4.9 |
|
3A |
<0.000012 |
<-4.9 |
<-4.9 |
3B |
<0.000012 |
<-4.9 |
|
Average experiments 1 to 3 |
<0.000012 |
|
<-4.9 |
Description of key information
Under the study conditions, the log Kow of the test substance was found to be <-4.9 at 25°C.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
