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EC number: 618-777-5
CAS number: 91662-51-0
Zeanyne salt was evaluated for mutagenic activity in the Ames test. A
standard plate incorporation and a
preincubation modification assay in absence and in presence of an
metabolic activation system (S9) were performed. Five Salmonella
typhimurium tester strains (TA1535, TA97, TA98, TA100, and TA102) were
employed. The activity of the S9-mix and the responsiveness of the
tester strains were verified by including
appropriate controls into each experiment.
The substance was dissolved in dimethylsulfoxide (DMSO). Toxic effects
were observed in a preliminary toxicity experiment starting at 333
ug/plate (on VB plates).
Therefore the concentration range 2 to 200 pg/plate was evaluated in the
main experiments. Upon addition to the aqueous medium no precipitation
of the compound was observable. Strain dependent toxic effects were
observed (reduction in the number
of revertants and/or reduction in the background growth). Using the
modification assay, known to be more sensitive for several class of
toxic effects were more pronounced. No increase of the number of mutant
colonies was apparent in any of the five investigated
tester strains. Thus it can be concluded, that neither Zeanyne salt per
se, nor any of the formed
metabolites was mutagenic in the Ames test under the described
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