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EC number: 618-777-5
CAS number: 91662-51-0
Single dose administration of 2000 mg/kg or 500 mg/kg induced laborious
breathing or increased salivation. Several animals died or were
sacrificed in a
moribund condition within a few days after dosing. In general, the cause
condition or death of the rats remained unclear. The findings in the
tract are indicative of functional disturbances. The marked difficulties
in breathing might
be due to the distention of the stomach, although it was not noted in
animals. The pathogenesis of the tubulonephrosis observed in one female
is unclear. It
might be related to the extreme body weight loss probably with resulting
observed in this animal.
The acute oral toxicity of Zeanyne salt was investigated in Wistar rats
Single dose administration of 500 mg/kg or 2000 mg/kg of Zeanyne salt
induced laborious or stertorous breathing or increased salivation. At
2000 mg/kg, 7/10 rats and at 500 mg/kg, 2/10 rats died or were
sacrificed in a moribund condition
within a few days after dosing. At necropsy, a distention of the
gastrointestinal tract and/or an abnormal intestinal content were found
in some of the rats which died or were sacrificed prematurely. These
findings are indicative of functional disturbances.
Microscopic findings in the lungs and kidneys observed in individual
animals are considered not to be directly related to treatment.
Single dose administration of 500 mg/kg in the rat induced severe
adverse effects and deaths. In general, the cause of poor
condition or death of the rats is unclear.
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