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EC number: 618-777-5
CAS number: 91662-51-0
To assess the primary skin irritation potential of Zeanyne salt, a
primary skin irritation
study was performed in three (one male and two females) young adult New
Zealand White rabbits.
The fur of the left flank was clipped and 0.5 g of the substance was
to an area of approximately 6 cm2 and then covered with a semi-occlusive
approximately 4 hours. After removal of the dressing and test article,
the skin reactions
(erythema and eschar, as well as oedema formation) were evaluated at 1,
24, 48 and 72 hours
after application. The primary irritation score was calculated to
reflect and classify the irritant
potential of the test article.
The dermal exposure to Zeanyne salt caused very slight erythema and
oedema in one
animal from one to 72 hours. Slight scaling of the skin was noted after
72 hours in this
animal. Well-defined erythema with marked scaling, scattered skin
fissures (partly open and
bleeding) were recorded after 7 days. Only slightly shiny skin was noted
after 14 days. No
findings were observed in the remaining two animals at any time during
The Primary Irritation Score for this substance was 0.67 (the maximum
attainable score is 8.0).
Following evaluation of the experimental data according to the EEC
classification criteria, Zeanyne salt is classified as "not irritating"
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