Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-647-4 | CAS number: 2211-28-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: detailed report not available: information about purity of the substance missing.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The tests were carried out in the usual manner, using 10 animals per dosage group.
The routes of administration were oral (by gavage). The lethal doses were
determined by the computer method. The LD 10, LD 50, and LD 90 are stated for observation periods of
24 hours and of 10 days. - GLP compliance:
- no
- Test type:
- other: internal description
- Limit test:
- no
Test material
- Reference substance name:
- 4-hydroxy-2-methylnaphthyl benzoate
- EC Number:
- 218-647-4
- EC Name:
- 4-hydroxy-2-methylnaphthyl benzoate
- Cas Number:
- 2211-28-1
- Molecular formula:
- C18H14O3
- IUPAC Name:
- 4-hydroxy-2-methyl-1-naphthyl benzoate
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- no dose range available
- No. of animals per sex per dose:
- 10 per dose
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 40 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: after 10 days
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 value for Monobenzoate is > 40.000 mg/kg (mouse)
- Executive summary:
-
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
