Registration Dossier
Registration Dossier
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EC number: 231-554-3 | CAS number: 7631-99-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The reliability and summary were made based on the HPV program adopted during OECD SIAM 25 (October 2007).
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of sodium nitrate aerosol on cardiopulmonary function of dogs, sheep, and man.
- Author:
- Sackner, M.A., Dougherty, R.D., Chapman, G.A., Zarzecki, S., Zarzemski, L., and Schreck, R.
- Year:
- 1 979
- Bibliographic source:
- Environmental Research 18:421-436.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Sodium nitrate
- EC Number:
- 231-554-3
- EC Name:
- Sodium nitrate
- Cas Number:
- 7631-99-4
- Molecular formula:
- HNO3.Na
- IUPAC Name:
- sodium nitrate
- Test material form:
- solid: crystalline
- Details on test material:
- - Physical appearance: not indicated
- Purity: not indicated
- Batch No.: not indicated
- Supplier: not indicated
Constituent 1
Test animals
- Species:
- dog
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- not specified
- Doses:
- 1, 10, and 100 mg
- No. of animals per sex per dose:
- 5 dogs
- Control animals:
- no
Results and discussion
Effect levels
- Dose descriptor:
- other: respiratory resistance, lung compliance, specific lung compliance, pulmonary arterial pressure, systemic arterial pressure, cardiac output, heart rate, stroke volume, and arterial blood gases.
- Effect level:
- >= 100 other: mg
- Remarks on result:
- other: no effects
Any other information on results incl. tables
Intravenous injection of 1, 10, and 100 mg sodium nitrate did not significantly affect respiratory resistance, lung compliance, specific lung compliance, pulmonary arterial pressure, systemic arterial pressure, cardiac output, heart rate, stroke volume, and arterial blood gases.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
