Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 271-678-5 | CAS number: 68603-87-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Animals were dosed with 40% aqueous solutions for 24 hours and observed for 14 days.
one female rabbit was dosed with 5010 mg/kg.
one female and one male rabbit were dosed with 7940 mg/kg - GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Carboxylic acids, di-, C4-6
- EC Number:
- 271-678-5
- EC Name:
- Carboxylic acids, di-, C4-6
- Cas Number:
- 68603-87-2
- Molecular formula:
- C5H8O4, C4H6O4, C6H10O4
- IUPAC Name:
- Carboxylic acids, C4-6 di-
- Details on test material:
- Dibasic acid concentrate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- water
- Duration of exposure:
- 24 hours
- Doses:
- 5010 and 7940 mg/kg
- No. of animals per sex per dose:
- 5010 group: one female
7940 mg/kg group: one female and one male - Control animals:
- not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 7 940 mg/kg bw
Any other information on results incl. tables
Signs of intoxication: wieght loss (two to four days)
Gross autopsy: viscera appeared normal
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD0 > 7940 mg/kg
- Executive summary:
No mortality was reported in an acute dermal toxicity experiment in rabbits following administration of 5010 mg/kg (n=1) or 7940 mg/kg (n=2) of a 40% aqueous solution/suspension of dicarboxylic acid mixture. The only clinical signs reported were weight loss during the first 2 to 4 days. The viscera appeared normal at termination after 14 days. The LD50 was thus > 7940 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
