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EC number: 273-769-5
CAS number: 69012-72-2
Residue from treatment of calcined zinc ore concentrates with antimony trioxide, zinc dust, lead oxide and copper sulfate. Consists primarily of zinc and a composite of metallics: cobalt, copper and lead.
Tissue damage in gastric and
intestinal epithelium, liver kidney and testes was graded
from 0 (no apparent damage) to 3 by a pathologist. Average
score for the group was then calculated and a weighted score
was determined by use of a table reported below.
Criteria used for assessment of cadmium-induced tissue damage
from histological scores
Average score in individual tissues
≤ 0.5≥ 0.5
Cd dose (µmol/kg)
A study was
conducted to determine the acute toxicity of the test material to mice.
No GLP or test guideline was reported.
Groups of 20
mice were administered CdCl2 at doses of 0, 5, 35, 70, 140,
270, 530, and 790 µmol Cd/kg bw (corresponding to 0, 0.6, 3.9, 7.9,
15.9, 30.7, 60.2, and 89.9 mg Cd/kg bw), as a single dose by gavage. The
animals were observed for mortality and clinical signs for 10 d and
thereafter sacrificed. Histological examination of the major organs was
done post necropsy.
dose-effect relation for tissue damage occurring among the surviving
mice at 10 d after exposure was observed. Major effects were seen in the
proximal parts of the intestinal tract. Catarrhal gastro-enteritis with
hyperaemia, haemorrhagic gastro-enteritis with epithelial desquamation,
or even necrosis of the entire epithelium with severe haemorrhage were
observed in the stomach, duodenum, and although less severe, in the
small intestine. Damage to liver and kidneys was only slight but
extensive testicular necrosis was found at the highest dose. The LD50 of
the test material was estimated to be between 530 - 790 µmol (60.2 -
89.9 mg) Cd/kg bw.
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