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EC number: 273-769-5
CAS number: 69012-72-2
Residue from treatment of calcined zinc ore concentrates with antimony trioxide, zinc dust, lead oxide and copper sulfate. Consists primarily of zinc and a composite of metallics: cobalt, copper and lead.
RATED BY AN INDEPENDENT REVIEWER.
SUMMARY DEVELOPED BY AN INDEPENDENT REVIEWER.
Robust Summary for SLI
The potential irritant/corrosive effects of the test substance were
evaluated using male and female adult New Zealand White rabbits, obtained
from Myrtle's Rabbitry, Thompson Station, TN, USA. Test animals were
individually housed under constant conditions of temperature (19-21 deg.
C), relative humidity (20-50%), and photoperiod (12-hr light/dark cycle).
Food and water were provided ad libitum.
Approximately 24 hours pre-exposure, a patch of fur on the dorsal trunk
area of three test animals was removed by close-clipping. One animal had
3 separate skin sites prepared. The test substance (0.5 g moistened with deionized water) was applied to the exposed skin via a semi-occlusive
gauze patch. The patches were kept in contact with the skin for periods of 3 minutes, 1 hour, and 4 hours (respectively, for the animal with 3
exposure sites), and 4 hours (for the remaining animals with only a single exposure site).
After the respective exposure periods, the patches were removed and
residual test material was removed using water. The exposed skin sites
were observed and evaluated for up to 72 hours following application.
Animals were observed twice daily, and unusual observations and/or
mortality were recorded. Animals were examined for signs of erythema and
edema, and reactions were scored according to the Macroscopic Dermal
Grading System based on Draize (1959). The 4-hour exposure data were
classified according to EEC guidelines (1983) and mean scores were
calculated to obtain Primary Irritation Indexes (PIIs) for erythema and edema.
Exposure to the test substance for 3 minutes produced no dermal
Exposure to the test substance for 1 hour produced very slight erythema, which resolved completely by 48 hours.
Exposure to the test substance for 4 hours produced very slight erythema
on 3/3 test animals one hour following patch removal. The dermal
irritation observed resolved completely in all test animals by the 48-h
Mean erythema score = 0.42 (nonirritant)
Mean edema score = 0.00 (nonirritant)
Under the conditions of the test, there was no evidence that nickel
sulfate hexahydrate was corrosive to the exposed skin of male and female
adult New Zealand White rabbits during exposure periods of 3 minutes, 1
hour, or 4 hours.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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