Registration Dossier
Registration Dossier
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EC number: 203-881-1 | CAS number: 111-55-7
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
EPI Suite v4.11 Estimation Programs Interface Suite™ for Microsoft® Windows v 4.11. US EPA, United States Environmental Protection Agency, Washington, DC, USA. - Qualifier:
- according to guideline
- Guideline:
- other:
- Version / remarks:
- REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- - Software tool(s) used including version: EPI Suite v4.11
- Model(s) used: HYDROWIN v2:00
Full reference and details of the used formulas can be found in:
Mill, T., Haag, W., Penwell, P., Pettit, T. and Johnson, H. "Environmental Fate and Exposure Studies Development of a PC-SAR for Hydrolysis: Esters, Alkyl Halides and Epoxides". EPA Contract No. 68-02-4254: SRI International (1987).
- Model description: see field 'Justification for non-standard information', 'Attached justification' and 'any other information on material and methods'
- Justification of QSAR prediction: see field 'Justification for type of information', 'Attached justification' and/or 'overall remarks' - GLP compliance:
- no
- Estimation method (if used):
- - Total Kb for pH > 8: 5.264E-001 L/mol sec
- Temperature for which rate constant was calculated: 25 °C
- Computer programme: HYDROWIN v2.00 - pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 152.39 d
- pH:
- 8
- Temp.:
- 25 °C
- DT50:
- 15.24 d
- Details on results:
- For detailed description on the model and its applicability, see "Any other information on materials and methods incl. tables".
Reference
Result refers to the uncharged molecule.
Description of key information
Hydrolysis is not considered to be a relevant abiotic degradation process.
Key value for chemical safety assessment
Additional information
No experimental studies investigating the abiotic hydrolysis of ethylene diacetate (CAS 111-55-7) are available. However, in accordance with Annex VIII, column 2, 9.2.2.1. of Regulation (EC) 1907/2006, testing is not required since the substance is readily biodegradable. In addition, a supporting QSAR calculation (HYDROWIN v2.00) indicates, that hydrolysis is a negligible pathway for the environmental fate of ethylene diacetate in the environment (DT50: 152.39 d (pH 7) and 15.24 d (pH 8)).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
