Registration Dossier
Registration Dossier
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EC number: 276-957-5 | CAS number: 72869-86-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984-05-08 - 1984-05-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-complience and according to OECD 401
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- First Amendment: Change in body weight range.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 7,7,9(or 7,9,9)-trimethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-1,16-diyl bismethacrylate
- EC Number:
- 276-957-5
- EC Name:
- 7,7,9(or 7,9,9)-trimethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-1,16-diyl bismethacrylate
- Cas Number:
- 72869-86-4
- Molecular formula:
- C23H38N2O8
- IUPAC Name:
- 7,7,9(or 7,9,9)-trimethyl-4,13-dioxo-3,14-dioxa-5,12-diazahexadecane-1,16-diyl bismethacrylate
- Details on test material:
- - Name of test material (as cited in study report): Diurethane Dimethacrylate
- Physical state: high viscous
- Analytical purity: 100 %
- Lot/batch No.: 16/81/399/52a
- Stability under test conditions: minimum of 2 hours
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 5 males and 5 females, 9-11 weeks,
body weight: males: 200-234 g, females: 167-182 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- vehicle: 2 % solution of CMC in distilled water
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- 0%
- Clinical signs:
- Dyspnea, curved body position and ruffled fur was observed in all rats within 1 to 5 hours after dosing.
- Body weight:
- no abnormal changes.
- Gross pathology:
- No macroscopic organ changes were observed.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 >5000 mg/kg, no classification
- Executive summary:
The following death rate was observed:
0 % at 5000 mg/kg body weight.
The LOGIT-Model could not be applied to these data.
The acute oral LD50 in rats of both sexes, observed over a period of 15 days, was estimated to be greater than 5000 mg/kg.
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