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EC number: 604-569-1
CAS number: 147126-62-3
Body weights of rats
Dose (mg/kg bw/day)
Mean body weights (g)
Final weight relative to vehicle controls (%)
X ± Y
In conclusion, analysis of all generated data, including clinical
observations, clinical pathology, gross necropsy and histopathology
revealed no test item related toxicity in rats treated orally at 62.5
and 125.0 mglkg/day for 28 days. Some animals treated with the test item
at 250.0 mglkg/day exhibited weight loss, piloerection, lethargy, local
irritation of the mucosa of the stomach due to local irritation and
hepatic steatosis. Female animals appeared more affected than males
indicating that there may be a gender difference in response to the
treatment. Lack or lower intensity of these observations in the recovery
animals was suggestive of the reversibility of the pathologic processes
induced by the test item.
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