Registration Dossier

Administrative data

Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17.08.2004 to 07.12.2004
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP- Study performed

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2004
Report date:
2004

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Principles of method if other than guideline:
The melting point was measured using a Mettler FP61 melting point apparatus, which ' employs a photocell detector to determine the melting point. Samples were contained in glass capillary tubes, 1.5-2 mm ID., Fisher Scentific; photocell detection, range: 0- 300 °C with Mettler FP61.
A preliminary test was done at a heating rate of 2 °C/minute to establish ·the .approximate melting point The final test was done at a heating rate of 0.2°C/minute starting at about 1 degree below the preliminary test value. Three measurements were made onthe sample material, along with4-(dimethyl ·amino) benzaldehyde as a reference.
Melting point of reference compound agreedwithin 0.5°C, of theoretical (73 °C measured, 74°C literature).
GLP compliance:
yes (incl. QA statement)
Type of method:
capillary method

Test material

Constituent 1
Reference substance name:
OS Menthol Ester
IUPAC Name:
OS Menthol Ester
Constituent 2
Chemical structure
Reference substance name:
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-hydroxy-1,3-oxathiolane-2-carboxylate
EC Number:
604-569-1
Cas Number:
147126-62-3
Molecular formula:
C14H24O4S
IUPAC Name:
(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-hydroxy-1,3-oxathiolane-2-carboxylate
Test material form:
solid: compact

Results and discussion

Melting / freezing point
Melting / freezing pt.:
> 95.44 - < 95.76 °C
Decomposition:
no
Sublimation:
no
Remarks on result:
other: measured at 369 K

Applicant's summary and conclusion

Conclusions:
We concluded from our observations that the test substance had a melting point of 95.6 +/- 0. 16°C, or 369 K.
(mean +/- standard deviation of 3 measurements)