Registration Dossier
Registration Dossier
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EC number: 211-470-3 | CAS number: 646-24-2
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2021-05-31 to 2021-09-17
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 794 g/L
- Temp.:
- 20 °C
- pH:
- ca. 13
- Conclusions:
- According to OECD Test Guideline 105 (1995) and Regulation (EC) No 440/2008 Method A.6. the water solubility at 20 °C of the test item NMDA was determined to be:
cS = 794 g/L
RSD = 2.2% - Endpoint:
- water solubility
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The result was obtained by the valid application of a well-established appropriate predictive method
- Principles of method if other than guideline:
- The water solubility of the substance was obtained using the SRC WATERNT property calculator.
- GLP compliance:
- no
- Water solubility:
- 35.2 g/L
- Temp.:
- 25 °C
- Remarks on result:
- other: no pH is given in the calculation
- Conclusions:
- A water solubility value of 35.2 g/L at 25°C was determined for the substance using an appropriate predictive method.
Very soluble (> 10000 mg/L) - Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The result is sourced from secondary literature (MSDS). There is sufficient evidence that the substane is water miscible.
- Principles of method if other than guideline:
- Experimental measurement (data is taken from a secondary source, information about the methodology is not available)
- GLP compliance:
- not specified
- Water solubility:
- 800 g/L
- Conclusions:
- A water solubility value of 800 g/l is reported in secondary literature. The original reference was not available for review and no further information is available. The reliability of this result is not assignable.
Referenceopen allclose all
Description of key information
According to OECD Test Guideline 105 (1995) and Regulation (EC) No 440/2008 Method A.6. the water solubility at 20 °C of the test item NMDA was determined to be:
cS = 794 g/L
RSD = 2.2%
Key value for chemical safety assessment
- Water solubility:
- 794 g/L
- at the temperature of:
- 20 °C
Additional information
According to OECD Test Guideline 105 (1995) and Regulation (EC) No 440/2008 Method A.6. the water solubility at 20 °C of the test item NMDA was determined to be:
cS = 794 g/L
RSD = 2.2%
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