Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Safety Evaluation of Silk Protein Film (A Novel Wound Healing Agent) in Terms of Acute Dermal Toxicity, Acute Dermal Irritation and Skin Sensitization
- Author:
- Amol R. Padol
- Year:
- 2 011
- Bibliographic source:
- Toxicology International / Vol-18 / Issue-1. 17-21 (2011)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- other: patch test with silk protein film
- Limit test:
- no
Test material
- Reference substance name:
- silk protein film
- Molecular formula:
- not applicable, UVCB
- IUPAC Name:
- silk protein film
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- physiological saline
- Duration of exposure:
- 24 hours
- Doses:
- patch test with films of silk proteins
- No. of animals per sex per dose:
- 6
- Control animals:
- yes, concurrent vehicle
Results and discussion
- Mortality:
- no
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Silk proteins did not cause acute dermal toxicity in rats.
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