[No public or meaningful name is available]

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Acute and Sub-acute Toxicities of Thai Silkworm Powder (Bombyx mori Linn.) From Three Races in Male Wistar Rats and In vitro Antioxidant Activities

Author:

Surapong Rattana1

Year:

2017

Bibliographic source:

Pharmacogn J. 2017; 9(4): 541-545

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

not specified

Remarks:

Literature data, GLP not stated

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

not applicable, UVCB

Molecular formula:

not applicable, UVCB

IUPAC Name:

not applicable, UVCB

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Doses:

silkworm powder from 3 races at dose of 1,000, 1,500 and 2,000 mg/kg b.w.

No. of animals per sex per dose:

10 groups, 6 rats per group

Control animals:

yes

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

none

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The LD50 was reported as > 2000 mg/kg bw.

Executive summary:

The LD50 was reported as > 2000 mg/kg bw.