Registration Dossier
Registration Dossier
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EC number: 203-470-7 | CAS number: 107-18-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- QSAR prediction for skin sensitisation (CAESAR)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Study period:
- 2017-09-05
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- Please refer to the OPRF and QMRF report attached in section Attached Justification.
Data source
Reference
- Title:
- Skin Sensitization model (CAESAR) 2.1.6
- Author:
- Emilio Benfenati Istituto di Ricerche Farmacologiche Mario Negri Via Giuseppe La Masa, 19, 20156
Milano (Italy) coord@caesar-project.eu http://www.caesar-project.eu - Year:
- 2 010
- Bibliographic source:
- The model provides a qualitative prediction of skin sensitisation on mouse (local lymph node assay model). It is implemented inside the VEGA online platform, accessible at:http://www.vega-qsar.eu/
Materials and methods
Test guideline
- Guideline:
- other: REACH Guidance on QSARs R.6
- Principles of method if other than guideline:
- Skin sensitisation of Allyl alcohol was predicted with CAESAR model implemented in the VEGA tool.
Test material
- Reference substance name:
- Allyl alcohol
- EC Number:
- 203-470-7
- EC Name:
- Allyl alcohol
- Cas Number:
- 107-18-6
- Molecular formula:
- C3H6O
- IUPAC Name:
- prop-2-en-1-ol
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Parameter:
- other: QSAR
- Remarks on result:
- no indication of skin sensitisation
- Remarks:
- Allyl alcohol is predicted 'negative'.
Any other information on results incl. tables
Allyl alcohol is predicted to be a non-sensitiser by the skin sensitization model CAESAR.
Applicant's summary and conclusion
- Conclusions:
- Allyl alcohol is not sensitising.
- Executive summary:
Skin sensitisation of Allyl alcohol was predicted with the Skin Sensitization model CAESAR 2.1.6, which is implemented in the QSAR tool VEGA (version 1.1.4.). Allyl alcohol is predicted to be "non sensitiser". This prediction is reliable, it is generated by a scientifically valid model and lies within the applicability domain (please refer also to the QPRF and QMRF attached in the section 'Attached Justification').
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