Registration Dossier
Registration Dossier
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EC number: 203-470-7 | CAS number: 107-18-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Data source
Reference
- Reference Type:
- publication
- Title:
- The toxicity of allyl alcohol
- Author:
- Dunlap, M.K., Kodama, J.K., Wellington, J.S., Anderson, H.H., Hine, C.H.
- Year:
- 1 958
- Bibliographic source:
- AMA Archives of Industrial Health. 18:303-311
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- no
Test material
- Reference substance name:
- Allyl alcohol
- EC Number:
- 203-470-7
- EC Name:
- Allyl alcohol
- Cas Number:
- 107-18-6
- Molecular formula:
- C3H6O
- IUPAC Name:
- prop-2-en-1-ol
- Details on test material:
- - Name of test material (as cited in study report): allyl alcohol
- Substance type: organic
- Physical state: liquid
- Analytical purity: 99%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 h
- Doses:
- 25 - 200 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- Toxicities in the lungs (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) were observed. The LD50 was 89 mg/kg bw.
- Executive summary:
Rabbits (3 males/group) were exposed for 24 hours to 25 - 200 mg/kg bw of 2-propen-1-ol (applied by injecting the 2-propen-1-ol though the occlusive dressing onto the surface of the skin and sealing the puncture site with rubber cement). Apathy, along with flushing of the skin, ataxia and diarrhoea were observed. On histopathological examination, toxicities in the lungs (congestion), liver (congestion and necrosis) and kidneys (heme casts and cloudy swelling) were observed. The LD50 was 89 mg/kg bw.
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