Registration Dossier
Registration Dossier
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EC number: 630-399-2 | CAS number: 130169-56-1
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
Weight of evidence is based on various studies performed according to guidelines and calculations with commercial software (kowwin, vers. 1.67)
Due to sorption characteristics and the potential to form aggregates a reliable measurement of the partition coefficient for primary fatty amines is impossible.
Thus, several studies were performed using C-chain pure amines (from dodecylamine to octadecylamine) and their respective hydrochloride salts to derive the corresponding solubilities in both water and n-octanol. In addition to that, literature values for the water solubilities of decylamine, dodecylamine and tetradecylamine are reported and values for hexadecylamine and octadecylamine were extrapolated thereof.
Also, the logKow is reported derived from commercially available software (kowwin Ver. 1.67) for the C-chain pure free primary amines.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 7
- at the temperature of:
- 25 °C
Additional information
Sorption characteristics and the potential to form aggregates prevent a reliable measurement of the partition coefficient for primary fatty amines.
Instead, several studies were performed to derive the solubilities of C-chain pure unprotonated and protonated (hydrochlorides) primary fatty amines in water and n-Octanol. The values derived in these studies were used to calculate the logKOW. Results indicate that the logKOW of the protonated form is within the range from 0.89 to 4.33 (see table 1).
Table 1
| log Pow | ||||
| C-Chainlength | calculated from solubilities in water (lit values) and n-octanol | calculated from solubilities in water (lit values) and n-octanol (hydrochlorides) | calculated from solubilities of hydrochlorides in water (cmc) and n-octanol | calculated from solubilities of hyrochlorides in water (cmc) and n-octanol (free amines) |
| C12 | 5.16 | 3.86 | 0.89 | 2.19 |
| C14 | 6.16 | 4.67 | 1.16 | 2.65 |
| C16 | 7.14 | 5.81 | 2.05 | 3.37 |
| C18 | 8.35 | 7.03 | 2.66 | 3.99 |
| C18:1 | 9.16 | 3.85 | 3.85 | 4.33 |
Although the primary fatty amines exhibit a pKa of about 10.6 - and thus appear fully protonated under environmental conditions - a value of about 7 for the logKOW is presented as worst case. This value is supported by logKOW calculations using commercially available software (like kowwin Version 1.67) (see table 2).
Table 2: logKow calculated from commercially available software (kowwin, Vers. 1.67)
| C-Chainlength | log Kow |
| C12 | 4,76 |
| C14 | 5,75 |
| C16 | 6,73 |
| C18 | 7,71 |
| C18:1 | 7,50 |
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