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EC number: -
CAS number: -
The results show no measurable penetration of the C18:0 soap through rat
skin up to 24 h after application, but 0.2 µg/cm² of the C16:0 soap had
penetrated at 24 h. At the end of the experiment,i .e. 24 h after
application, between 60 and 70% of the applied [14C] soaps were rinsed
from the skin and 30-40% was associated with the skin.
The in vitro penetration of C16 and C18 fatty acids (as aqueous sodium salt solutions) through rat skin decreases with increasing chain length. Based on these findings the dermal absorption of fatty acids C16 and C18 present in the substance Triglycerides, C16-18 (even-numbered), reaction products with diethylenetriamine is considered to be low.
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