Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Adsorption / desorption

Currently viewing:

Administrative data

Link to relevant study record(s)

Referenceopen allclose all

Endpoint:
adsorption / desorption: screening
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
14 September 2015 - 13 February 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
An OECD 121 GLP study for a similar substance is available and is used within a read-across approach. The composition of source and target substance is described and discussed in detail in the attached supporting information as well as the read-across justification.
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
other: mobile phase
Specific details on test material used for the study:
Target substance:

Amidoamine 2 (UVCB, low nitrogen):
Former chemical name: Amides, from diethylenetriamine and hydrogenated palm oil
CAS No.: 1618093-67-6
New chemical name: Glycerides, C16-18 (even numbered) and their amidation products with diethylenetriamine
Physical state: pale yellowish solid at 20 °C
Batch No.: PU50070067
Purity: 100 % (UVCB)
Storage condition of test material: Room temperature, protected from light
Stability: stable under test conditions
Radiolabelling:
no
Test temperature:
30 °C
Details on study design: HPLC method:
The sample, dead time and reference standard solutions were injected in duplicate using the
following HPLC parameters:
HPLC System: Agilent Technologies 1200 Series
Detector types: Ultraviolet (VWD)
Evaporative light scattering (ELSD)
Column: Waters XSelect Cyano, 5 µm (150 x 4.6 mm id)
Column temperature: 30 °C

Mobile phase A: Methanol: water adjusted to pH ~3 using trifluoroacetic acid
Mobile phase B: Methanol: THF

A calibration curve was constructed from the retention time data of the dead time and reference standard solutions. The capacity factors, k', for the reference standards were calculated. A correlation of log k' versus log Koc of the calibration standards was plotted using linear regression.
Analytical monitoring:
yes
Details on sampling:
Test item was diluted to 100 mL with tetrahydrofuran (THF).
Details on matrix:
A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
Key result
Sample No.:
#1
Type:
log Koc
Value:
> 5.63 dimensionless
pH:
3
Temp.:
30 °C
Matrix:
HPLC column containing lipophilic and polar moieties
Key result
Sample No.:
#1
Type:
Koc
Value:
> 427 000 dimensionless
pH:
3
Temp.:
30 °C
Matrix:
HPLC column containing lipophilic and polar moieties
Details on results (HPLC method):
The test system utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The dead time was determined by measuring the retention time of formamide (purity: 99.94%, 0.612 g/L solution in mobile phase).
Solutions of reference standards, e.g. Acetanilide, Naphthalene and DDT were prepared in methanol. A calibration curve was constructed from the retention time data of the dead time and reference standard solutions. The mobility classification of the test item was obtained by comparing the calculated Koc
value to the mobility classes according to P.J. McCall, R.L. Swann, D.A. Laskowski, S.M. Unger, S.A. Vrona and H.J. Dishburger “Estimation of Chemical Mobility in Soil from Liquid Chromatography Retention Times”; Bull. Environm. Contam. Toxicol. 24, 190-195 (1980).
Validity criteria fulfilled:
yes
Conclusions:
The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10^5, log10 Koc > 5.63. These values indicate that the test item will be essentially immobile in the environment.
It is considered likely, that the target substance Amidoamine 2 (UVCB, low nitrogen) will have a comparable adsorption coefficient (Koc > 5) as Amidoamine (UVCB) based on the similar chemical composition.
Executive summary:

The adsorption and desorption of amidoamine test item was determined in a Klimisch 1 GLP study according to EC C.19 and OECD 121. The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10^5, log10 Koc >5.63. These values indicate that the test item will be essentially immobile in the environment. This study is considered relevant for the risk assessment. It is considered likely, that the target substance Amidoamine 2 (UVCB, low nitrogen) will have a comparable adsorption coefficient (Koc > 5) as Amidoamine (UVCB) based on the similar chemical composition. It is expected that the higher concentration of saturated mono- and diglycerides and the presence of saturated triglycerides in Amidoamine 2 (UVCB, low nitrogen) will have no significant effect on the partition coefficient.

Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
14 September 2015 - 13 February 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
other: mobile phase
Specific details on test material used for the study:
Test item without emulsifier was investigated.

Source substance:

Amidoamine (UVCB)
Pulcra ID: DE07_2014_012_BEL66 (amidoamine without emulsifier)
Former chemical name: Amides, from diethylenetriamine and hydrogenated palm oil
Former CAS No.: 1618093-67-6
New chemical name: Triglycerides, C16-18 (even-numbered), reaction products with diethylenetriamine
Physical state: pale yellowish solid at 20 °C
Batch No.: K8 4309 L481
Expiry date of batch: 09 March 2018
Purity: 100 % (UVCB)
Stability: stable under test conditions
Storage condition of test material: Room temperature, protected from light

Target substance:

Amidoamine 2 (UVCB, low nitrogen):
Former chemical name: Amides, from diethylenetriamine and hydrogenated palm oil
CAS No.: 1618093-67-6
New chemical name: Glycerides, C16-18 (even numbered) and their amidation products with diethylenetriamine
Physical state: pale yellowish solid at 20 °C
Batch No.: PU50070067
Purity: 100 % (UVCB)
Storage condition of test material: Room temperature, protected from light
Stability: stable under test conditions
Radiolabelling:
no
Test temperature:
30 °C
Details on study design: HPLC method:
The sample, dead time and reference standard solutions were injected in duplicate using the
following HPLC parameters:
HPLC System: Agilent Technologies 1200 Series
Detector types: Ultraviolet (VWD)
Evaporative light scattering (ELSD)
Column: Waters XSelect Cyano, 5 µm (150 x 4.6 mm id)
Column temperature: 30 °C

Mobile phase A: Methanol: water adjusted to pH ~3 using trifluoroacetic acid
Mobile phase B: Methanol: THF

A calibration curve was constructed from the retention time data of the dead time and reference standard solutions. The capacity factors, k', for the reference standards were calculated. A correlation of log k' versus log Koc of the calibration standards was plotted using linear regression.
Analytical monitoring:
yes
Details on sampling:
Test item was diluted to 100 mL with tetrahydrofuran (THF).
Details on matrix:
A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used.
Key result
Sample No.:
#1
Type:
log Koc
Value:
> 5.63 dimensionless
pH:
3
Temp.:
30 °C
Matrix:
HPLC column containing lipophilic and polar moieties
Key result
Sample No.:
#1
Type:
Koc
Value:
> 427 000 dimensionless
pH:
3
Temp.:
30 °C
Matrix:
HPLC column containing lipophilic and polar moieties
Details on results (HPLC method):
The test system utilized a high performance liquid chromatograph. A commercially available cyanopropyl reverse phase HPLC column containing lipophilic and polar moieties was used. The dead time was determined by measuring the retention time of formamide (purity: 99.94%, 0.612 g/L solution in mobile phase).
Solutions of reference standards, e.g. Acetanilide, Naphthalene and DDT were prepared in methanol. A calibration curve was constructed from the retention time data of the dead time and reference standard solutions. The mobility classification of the test item was obtained by comparing the calculated Koc
value to the mobility classes according to P.J. McCall, R.L. Swann, D.A. Laskowski, S.M. Unger, S.A. Vrona and H.J. Dishburger “Estimation of Chemical Mobility in Soil from Liquid Chromatography Retention Times”; Bull. Environm. Contam. Toxicol. 24, 190-195 (1980).
Validity criteria fulfilled:
yes
Conclusions:
The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10^5, log10 Koc >5.63. These values indicate that the test item will be essentially immobile in the environment.
Executive summary:

The adsorption and desorption of amidoamine test item was determined in a Klimisch 1 GLP study according to EC C.19 and OECD 121. The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10^5, log10 Koc >5.63. These values indicate that the test item will be essentially immobile in the environment. This study is considered relevant for the risk assessment.

Description of key information

The adsorption coefficient (Koc) of the test item has been determined to be greater than 4.27 x 10^5, log10 Koc >5.63.  These values indicate that the test item will be essentially immobile in the environment.


It is considered likely, that the target substance Amidoamine 2 (UVCB, low nitrogen) will have a comparable adsorption coefficient (Koc > 5) as Amidoamine (UVCB) based on the similar chemical composition. It is expected that the higher concentration of saturated mono- and diglycerides and the presence of saturated triglycerides in Amidoamine 2 (UVCB, low nitrogen) will have no significant effect on the partition coefficient.

Key value for chemical safety assessment

Koc at 20 °C:
427 000

Additional information

Log Koc: > 5.63


Koc: > 427000