Registration Dossier
Registration Dossier
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EC number: 601-147-9 | CAS number: 111988-49-9
Endpoint summary
Administrative data
Description of key information
DT50 in natural pond water at 21 °C: 58 to 118 days (135 to 274 days, recalculated to 12 °C).
DT50 in sediment at 20 °C: 12.1 to 20.3 days (25.7 to 43.1 days, recalculated to 12 °C), aerobic conditions
DT50 in sediment at 20 °C: > 1 year, anaerobic conditions
Additional information
No study on ready biodegradability is available (Z)-3-(6-chloro-3-pyridylmethyl)-1,3-thiazolidin-2-ylidenecyanamide. However, since higher tier studies on the biodegradation of the test substance in water, sediment and soil are available no additional study on ready biodegradability is necessary. The PBT assessment and environmental classification can be derived based on the available higher tier studies.
In a simulation study, the degradation of the target substance (Z)-3-(6-chloro-3-pyridylmethyl)-1,3-thiazolidin-2-ylidenecyanamide in natural pond water at 21 °C, according to GLP and OECD Guideline 309, was found to be 274 days at 12 °C (recalculated from experimental data at 20 °C). After 62 days of incubation, radioactive carbon dioxide did not exceed 0.9% of the applied radioactivity.
In a simulation study on the biodegradation in natural pond water/sediment systems revealed a half-life of the test substance of 43.1 days at 12 °C (recalculated from experimental data at 20 °C). After an incubation period of 100 days 14CO2 accounted for <5% of the initially applied radioactivity.
In soil, the target substance attained 6.5 to 33.6% degradation (elevation of 14CO2) after 100 days and 20 °C, and the half-life of the test substance in soil was found to range from 0.7 to 4.7 days (1.5 to 10 days, recalculated to 12 °C).
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