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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
(Z)-non-6-enal
EC Number:
218-900-9
EC Name:
(Z)-non-6-enal
Cas Number:
2277-19-2
Molecular formula:
C9H16O
IUPAC Name:
6-Nonenal, (6Z)-
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
5 g/kg
No. of animals per sex per dose:
10
Control animals:
no
Details on study design:
- Duration of observation period following administration: at least 8 days
- Necropsy of survivors performed: yes
- Clinical signs including body weight: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Statistics:
95% confidence limit

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
not specified
Mortality:
One of ten animals died on day 8 of the study.
Clinical signs:
Alopecia
Gross pathology:
Eight animals were normal at necropsy. One animals showed brown exudate fromt the anogenital area. One animal had red areas in the intestines. One animal had a dark liver, and one animal had dark areas of the lungs.

Any other information on results incl. tables

 

Number of Animals

Mortality on Day 8

1

Normal Necropsy

8

Exudate, Anogential, Brown

1

Intestines, Areas Red

1

Liver Dark

1

Lungs, Areas Dark

1

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute oral LD50 is greater than 5000 mg/kg.
Executive summary:

The acute oral toxicity of the test substance was tested by exposing 10 rats orally to 5,000 mg/kg of the test substance. One animal died eight days after exposure. The acute oral LD50 is therefore greater than 5000 mg/kg.