Reaction mass of disodium hexatitanium tridecaoxide and disodium trititanium heptaoxide

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study without detailed documentation

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2007

Report date:

2007

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

Deviations:

no

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Titanium dioxide

EC Number:

236-675-5

EC Name:

Titanium dioxide

Cas Number:

51745-87-0

Molecular formula:

O2Ti

IUPAC Name:

Titanium dioxide

Test material form:

solid: particulate/powder

Specific details on test material used for the study:

The study was conducted with four concentrations each of fine-sized rutile TiO 2 particles and ultrafine TiO 2 particles and a dilution water control at a mean temperature of 12.2 ◦ C (range of 12.1–12.3 ◦ C) and 12.2 ◦ C (range of 12.1–12.5 ◦ C), respectively. One test chamber was used per test substance concentration for each test substance with five test organisms in each chamber.

Sampling and analysis

Analytical monitoring:

not specified

Test organisms

Test organisms (species):

Oncorhynchus mykiss (previous name: Salmo gairdneri)

Study design

Test type:

static

Water media type:

freshwater

Total exposure duration:

96 h

Test conditions

Details on test conditions:

Based on visual observations, the dilution water controls, 0.1 and 1.0mg/L test concentrations were clear and colorless with no precipitate at test start. The 10 and 100mg/L test concentrations were cloudy with a slight amount of suspended substance present at test start. All water quality parameters were within acceptable limits during the exposure.

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Details on results:

Exposure of rainbow trout to a dilution water control and nominal fine TiO 2 and uf-C TiO 2 particle concentrations of 0.1, 1.0, 10, and 100mg/L resulted in 0, 0, 0, 10, and 10% or 0, 0, 0, 0, and 0% immobility, respectively, at the end of 96h.

Applicant's summary and conclusion

Conclusions:

The 96 h LC50 for both types of TiO 2 particles was >100mg/L based on nominal test concentrations. The results demonstrated that fine or uf-C TiO 2 particles each exhibited low concern for aquatic hazard for O. Mykiss in unaerated, 96h, static acute tests.