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EC number: 271-080-4
CAS number: 68515-39-9
A complex combination of hydrocarbons produced by the esterification of phthalic anhydride with tridecyl alcohol. It consists predominantly of C13 primary aliphatic alcohols, C11-13 paraffins and saturated and unsaturated C26 ethers and boiling in the range of approximately 120°C to 280°C (248°F to 536°F).
The EC3 value could not be calculated, since all S.I.´s are below the
threshold value of 3.
In order to study a possible skin sensitising potential of C13 Discard
Alcohol, three groups each of four female mice were treated once daily
with the study substance at concentrations of 2.5, 5, and 10% in
acetone/olive oil (4+1, v/v) by topical application to the dorsum of
each ear for three consecutive days. The highest concentration tested
was the highest concentration that could be achieved whilst avoiding
systemic toxicity and excessive local skin irritation as confirmed by a
pre-experiment. A control group of four mice was treated with the
vehicle (acetone/olive oil (4+1, v/v)) only. Five days after the first
topical application the mice were injected intravenously into a tail
vein with radio-labelled thymidine (3H-methyl thymidine). Approximately
five hours after intravenous injection, the mice were sacrificed, the
draining auricular lymph nodes excised and pooled per group. Single cell
suspensions of lymph node cells were prepared from pooled lymph nodes,
which were subsequently washed and incubated with trichloroacetic acid
overnight. The proliferative capacity of pooled lymph node cells was
determined by the incorporation of 3H-methyl thymidine measured in a
All treated animals survived the scheduled study period and no signs of
systemic toxicity were observed. The animals treated with the study
substance showed a very slight erythema of the ear skin (Score 1).
A study substance is regarded as a sensitiser in the LLNA if the
exposure to one or more test concentration resulted in a 3-fold or
greater increase in incorporation of 3HTdR compared with concurrent
controls, as indicated by the Stimulation Index (S.I.). The estimated
concentration of study substance required to produce a S.I. of 3 is
referred to as the EC3 value.
In this study, Stimulation Indices of 1.44, 1.63, and 1.23 were
determined with the study substance at concentrations of 2.5, 5, and 10%
in acetone/olive oil (4+1, v/v). The EC3 value could not be calculated,
since none of the tested concentrations induced a S.I. greater than the
threshold value of 3.
The study substance was not a skin sensitiser under the test conditions
of this study.
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